Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0FV9Y
|
|||
| Former ID |
DNC008201
|
|||
| Drug Name |
PhSO2-Gly-(Me-Gly)-Arg-(2-thiazole)
|
|||
| Synonyms |
CHEMBL403629
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C20H27N7O5S2
|
|||
| Canonical SMILES |
CN(CC(=O)NC(CCCN=C(N)N)C(=O)C1=NC=CS1)C(=O)CNS(=O)(=O)C2=CC=CC=C2
|
|||
| InChI |
1S/C20H27N7O5S2/c1-27(17(29)12-25-34(31,32)14-6-3-2-4-7-14)13-16(28)26-15(8-5-9-24-20(21)22)18(30)19-23-10-11-33-19/h2-4,6-7,10-11,15,25H,5,8-9,12-13H2,1H3,(H,26,28)(H4,21,22,24)/t15-/m0/s1
|
|||
| InChIKey |
GJNJUHMPYZAMBU-HNNXBMFYSA-N
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Coagulation factor Xa (F10) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Complement and coagulation cascades | |||
| Panther Pathway | Blood coagulation | |||
| Pathwhiz Pathway | Coagulation | |||
| Pathway Interaction Database | Beta2 integrin cell surface interactions | |||
| Reactome | Extrinsic Pathway of Fibrin Clot Formation | |||
| Intrinsic Pathway of Fibrin Clot Formation | ||||
| Common Pathway of Fibrin Clot Formation | ||||
| Gamma-carboxylation of protein precursors | ||||
| Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus | ||||
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | ||||
| WikiPathways | Complement and Coagulation Cascades | |||
| Human Complement System | ||||
| PTM: gamma carboxylation, hypusine formation and arylsulfatase activation | ||||
| Blood Clotting Cascade | ||||
| Formation of Fibrin Clot (Clotting Cascade) | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem. 2008 Feb 15;16(4):1562-95. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.