Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0G3IT
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| Former ID |
DNC010810
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| Drug Name |
RU-56187
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| Synonyms |
RU-56187; 143782-25-6; CHEMBL1099140; 4-(3,4,4-Trimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile; Benzonitrile,2-(trifluoromethyl)-4-(3,4,4-trimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-; RU 56187; ACMC-20n377; AC1L318J; SCHEMBL1435262; CTK4C3806; DTXSID90162545; BDBM50317664; 2-(trifluoromethyl)-4-(3,4,4-trimethyl-5-oxo-2-sulfanylideneimidazolidin-1-yl)benzonitrile; 2-(trifluoromethyl)-4-(3,4,4-trimethyl-5-oxo-2-thioxoimidazolidin-1-yl)benzonitrile; Benzonitrile, 2-(trifluoromethyl)-4-(3,4,4-trimet
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C14H12F3N3OS
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| Canonical SMILES |
CC1(C(=O)N(C(=S)N1C)C2=CC(=C(C=C2)C#N)C(F)(F)F)C
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| InChI |
1S/C14H12F3N3OS/c1-13(2)11(21)20(12(22)19(13)3)9-5-4-8(7-18)10(6-9)14(15,16)17/h4-6H,1-3H3
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| InChIKey |
HLBUAKQNKJTEIU-UHFFFAOYSA-N
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| CAS Number |
CAS 143782-25-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Androgen receptor messenger RNA (AR mRNA) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Oocyte meiosis | |||
| Pathways in cancer | ||||
| Prostate cancer | ||||
| NetPath Pathway | EGFR1 Signaling Pathway | |||
| AndrogenReceptor Signaling Pathway | ||||
| FSH Signaling Pathway | ||||
| Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | |||
| Coregulation of Androgen receptor activity | ||||
| Regulation of Androgen receptor activity | ||||
| Nongenotropic Androgen signaling | ||||
| Regulation of nuclear beta catenin signaling and target gene transcription | ||||
| FOXA1 transcription factor network | ||||
| Notch-mediated HES/HEY network | ||||
| Reactome | Nuclear Receptor transcription pathway | |||
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Integrated Pancreatic Cancer Pathway | ||||
| Prostate Cancer | ||||
| Integrated Breast Cancer Pathway | ||||
| Nuclear Receptors | ||||
| Androgen receptor signaling pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Structure-activity relationships of bioisosteric replacement of the carboxylic acid in novel androgen receptor pure antagonists. Bioorg Med Chem. 2010 May 1;18(9):3159-68. | |||
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