Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0G3RN
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| Former ID |
DNC008439
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| Drug Name |
VUF-10214
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| Synonyms |
VUF-10214; CHEMBL260549; SCHEMBL602698; BDBM50361014; 6,7-dichloro-3-(4-methylpiperazin-1-yl)quinoxalin-2(1 h)-one
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C13H14Cl2N4O
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| Canonical SMILES |
CN1CCN(CC1)C2=NC3=CC(=C(C=C3NC2=O)Cl)Cl
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| InChI |
1S/C13H14Cl2N4O/c1-18-2-4-19(5-3-18)12-13(20)17-11-7-9(15)8(14)6-10(11)16-12/h6-7H,2-5H2,1H3,(H,17,20)
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| InChIKey |
MFJVHWQDKIEBCM-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H3 receptor (H3R) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Histamine receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Monoamine Transport | |||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo. J Med Chem. 2008 Apr 24;51(8):2457-67. | |||
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