Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0G4ES
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| Former ID |
DIB009092
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| Drug Name |
Tetrandrine
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| Synonyms |
Tetrandrine, Millenia Hope; Tetrandrine, West Virginia University; Tranex-18
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| Drug Type |
Small molecular drug
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| Indication | Sarcoma [ICD-11: 2A60-2C35; ICD-10: C81-C86; ICD-9: 202.8] | Phase 1 | [1] | |
| Colorectal cancer [ICD-11: 2B91.Z] | Discontinued in Phase 3 | [2] | ||
| Company |
West Virginia University
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| Structure |
 |
Download2D MOL |
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| Formula |
C38H42N2O6
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| Canonical SMILES |
CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)OC)OC
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| InChI |
1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30-/m0/s1
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| InChIKey |
WVTKBKWTSCPRNU-KYJUHHDHSA-N
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| CAS Number |
CAS 518-34-3
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:49
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Calcium channel unspecific (CaC) | Target Info | Antagonist | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022136) | |||
| REF 3 | Tetrandrine: a novel calcium channel antagonist inhibits type I calcium channels in neuroblastoma cells. Neuropharmacology. 1991 Dec;30(12A):1325-31. | |||
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