Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0G5AG
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| Former ID |
DAP001404
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| Drug Name |
Mizoribine
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| Synonyms |
Bredinin; Bredinine; MZR; Mizoribina; Mizoribinum; M 3047; Bredinin (TN); HE-69; HS-0046; Mizoribina [INN-Spanish]; Mizoribine [INN:JAN]; Mizoribinum [INN-Latin]; Mizoribine (JAN/INN); Bredinin, HE 69, NSC 289637, MZB, Mizoribine; Anhydro-4-carbamoyl-5-hydroxy-1-beta-D-ribofuranosyl-imidazolium hydroxide; N'-(beta-D-Ribofuranosyl)-5-hydroxyimidazole-4-carboxamide; N'-(beta-D-Ribofuranosyl)-5-hydroxy-imida-zole-4-carboxamide; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxyimidazole-4-carboxamide;4-Carbamoyl-1-beta-D-ribofuranosyl-imidazolium-5-olate; 4-carbamoyl-1-b-d-ribofuranosylimidazolium-5-olate; 5-Hydroxy-1-beta-D-ribofuranosyl-1H-imidazole-4-carboxamide; 5-Hydroxy-1-beta-D-ribofuranosylimidazole-4-carboxamide
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| Drug Type |
Small molecular drug
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| Indication | Transplant rejection [ICD-11: NE84] | Approved | [1], [2] | |
| Therapeutic Class |
Antimetabolites
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| Structure |
 |
Download2D MOL |
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| Formula |
C9H13N3O6
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| Canonical SMILES |
C1=NC(=C(N1C2C(C(C(O2)CO)O)O)O)C(=O)N
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| InChI |
1S/C9H13N3O6/c10-7(16)4-8(17)12(2-11-4)9-6(15)5(14)3(1-13)18-9/h2-3,5-6,9,13-15,17H,1H2,(H2,10,16)/t3-,5-,6-,9-/m1/s1
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| InChIKey |
HZQDCMWJEBCWBR-UUOKFMHZSA-N
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| CAS Number |
CAS 50924-49-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
815565, 7848455, 8150076, 10233595, 11336123, 11361362, 11371618, 11373998, 11462334, 11485174, 11489375, 11490555, 11492035, 11532986, 12013753, 14750114, 14798922, 14872303, 15196996, 17405306, 24278546, 26679836, 37235031, 44434374, 47515385, 47515386, 47736571, 47959845, 48259320, 49979230, 50106568, 50106569, 50106570, 50303271, 53777851, 56424022, 57337827, 90340602, 91010689, 92304153, 92721415, 92729691, 93815047, 99302036, 99431405, 99437125, 103138275, 103525173, 104372869, 117565393
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| ChEBI ID |
CHEBI:31858
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) | Target Info | Inhibitor | [3], [4] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 3 | VX-497: a novel, selective IMPDH inhibitor and immunosuppressive agent. J Pharm Sci. 2001 May;90(5):625-37. | |||
| REF 4 | Cofactor mimics as selective inhibitors of NAD-dependent inosine monophosphate dehydrogenase (IMPDH)--the major therapeutic target. Curr Med Chem. 2004 Apr;11(7):887-900. | |||
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