Drug Information
Drug General Information | Top | |||
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Drug ID |
D0G5LZ
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Former ID |
DNC011375
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Drug Name |
GNF-PF-1591
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Synonyms |
GNF-Pf-1591; MLS000554446; SMR000171400; AC1LKBEY; ChemDiv2_001930; CBMicro_025972; MAIM-1; CHEMBL588954; HDOKKAMQZREOLG-XQNSMLJCSA-N; 4-methyl-N-[4-oxo-3-(1H-1,2,4-triazol-5-ylsulfanyl)naphthalen-1-ylidene]benzenesulfonamide; HMS2542H12; ZINC18213201; ZINC100480724; MCULE-5187110916; J3.505.787K; SR-01000708580; SR-01000708580-2
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C19H14N4O3S2
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Canonical SMILES |
CC1=CC=C(C=C1)S(=O)(=O)N=C2C=C(C(=O)C3=CC=CC=C32)SC4=NC=NN4
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InChI |
1S/C19H14N4O3S2/c1-12-6-8-13(9-7-12)28(25,26)23-16-10-17(27-19-20-11-21-22-19)18(24)15-5-3-2-4-14(15)16/h2-11H,1H3,(H,20,21,22)
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InChIKey |
HDOKKAMQZREOLG-UHFFFAOYSA-N
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CAS Number |
CAS 315698-91-0
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) | Target Info | Inhibitor | [1] |
KEGG Pathway | PI3K-Akt signaling pathway | |||
MicroRNAs in cancer | ||||
NetPath Pathway | TCR Signaling Pathway | |||
Panther Pathway | Apoptosis signaling pathway | |||
CCKR signaling map ST | ||||
Pathway Interaction Database | E2F transcription factor network | |||
Direct p53 effectors | ||||
IL6-mediated signaling events | ||||
HIF-1-alpha transcription factor network | ||||
WikiPathways | Apoptosis | |||
miR-targeted genes in muscle cell - TarBase | ||||
miR-targeted genes in lymphocytes - TarBase | ||||
miR-targeted genes in leukocytes - TarBase | ||||
Apoptosis Modulation and Signaling |
References | Top | |||
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REF 1 | In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. |
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