Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0GA5T
|
|||
| Former ID |
DAP001484
|
|||
| Drug Name |
Indiplon
|
|||
| Synonyms |
NBI 34060; NBI-34060; Indiplon (USAN/INN); N-methyl-N-[3-[3-(thiophene-2-carbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]acetamide
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Fibromyalgia [ICD-11: MG30.01; ICD-10: M79.7] | Approved | [1], [2] | |
| Insomnia [ICD-11: 7A00-7A0Z] | Approved | [1], [2] | ||
| Company |
Neurocrine Biosciences
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C20H16N4O2S
|
|||
| Canonical SMILES |
CC(=O)N(C)C1=CC=CC(=C1)C2=CC=NC3=C(C=NN23)C(=O)C4=CC=CS4
|
|||
| InChI |
1S/C20H16N4O2S/c1-13(25)23(2)15-6-3-5-14(11-15)17-8-9-21-20-16(12-22-24(17)20)19(26)18-7-4-10-27-18/h3-12H,1-2H3
|
|||
| InChIKey |
CBIAWPMZSFFRGN-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 325715-02-4
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
11972267, 12015274, 14755671, 17396810, 43041857, 52196169, 57370225, 58108256, 92721148, 93308995, 103570256, 114525918, 126627716, 126652167, 126667075, 134338676, 135238165, 135367559, 135697686, 136352571, 137185869, 142053913, 152048943, 163121936, 164044009, 164227502, 164761174, 164761175, 174006212, 178101038, 179150321, 196106489, 198954185, 204371014, 223667834, 223791526, 226454824, 245214103, 252157388, 252159878
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor alpha-1 (GABRA1) | Target Info | Agonist | [2], [3] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4221). | |||
| REF 2 | Emerging therapies for fibromyalgia. Expert Opin Emerg Drugs. 2008 Mar;13(1):53-62. | |||
| REF 3 | Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.