Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0GN5Z
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| Former ID |
DNC011373
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| Drug Name |
SULFURETIN
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| Synonyms |
Sulfuretin; 120-05-8; Sulphuretin; UNII-M6410VY6MI; MLS000863576; M6410VY6MI; CHEBI:9355; SMR000440743; (Z)-2-[(3,4-dihydroxyphenyl)methylene]-6-hydroxy-2H-benzofuran-3-one; (2Z)-2-(3,4-Dihydroxybenzylidene)-6-hydroxy-1-benzofuran-3(2H)-one; 6,3',4'-Trihydroxyaurone; (2Z)-2-[(3,4-dihydroxyphenyl)methylidene]-6-hydroxy-1-benzofuran-3-one; (Z)-2-((3,4-Dihydroxyphenyl)methylene)-6-hydroxy-2H-benzofuran-3-one; Aurone, 6,3',4'-trihydroxy-; EINECS 204-366-4; AC1NQYB9; SCHEMBL634006; SCHEMBL634007
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C15H10O5
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| Canonical SMILES |
C1=CC(=C(C=C1C=C2C(=O)C3=C(O2)C=C(C=C3)O)O)O
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| InChI |
1S/C15H10O5/c16-9-2-3-10-13(7-9)20-14(15(10)19)6-8-1-4-11(17)12(18)5-8/h1-7,16-18H/b14-6-
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| InChIKey |
RGNXWPVNPFAADO-NSIKDUERSA-N
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| CAS Number |
CAS 120-05-8
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:9355
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | PI3K-Akt signaling pathway | |||
| MicroRNAs in cancer | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | Apoptosis signaling pathway | |||
| CCKR signaling map ST | ||||
| Pathway Interaction Database | E2F transcription factor network | |||
| Direct p53 effectors | ||||
| IL6-mediated signaling events | ||||
| HIF-1-alpha transcription factor network | ||||
| WikiPathways | Apoptosis | |||
| miR-targeted genes in muscle cell - TarBase | ||||
| miR-targeted genes in lymphocytes - TarBase | ||||
| miR-targeted genes in leukocytes - TarBase | ||||
| Apoptosis Modulation and Signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. | |||
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