Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0GP1O
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| Drug Name |
Emixustat
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| Synonyms |
EMIXUSTAT; UNII-02DZ1HBF0M; 1141777-14-1; 02DZ1HBF0M; Emixustat [USAN:INN]; (1R)-3-amino-1-[3-(cyclohexylmethoxy)phenyl]propan-1-ol; Incemixustat; ACU 4229; A3V; Emixustat (USAN); SCHEMBL966515; CHEMBL2107821; DTXSID50150665; WJIGGYYSZBWCGC-MRXNPFEDSA-N; ZINC59126886; AKOS032945088; CS-6177; DB12608; HY-19720; D10348; (r)-3-amino-1-(3-(cyclohexylmethoxy)phenyl)propan-1-ol; 3-Amino-1-[3-(cyclohexylmethoxy)phenyl]propan-1(R)-ol hydro -chloride
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| Drug Type |
Small molecular drug
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| Indication | Age-related macular degeneration [ICD-11: 9B75.0; ICD-9: 362.5] | Phase 2/3 | [1] | |
| Proliferative diabetic retinopathy [ICD-11: 9B71.01] | Phase 2 | [2] | ||
| Company |
Acucela Seattle, WA
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| Structure |
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Download2D MOL |
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| Formula |
C16H25NO2
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| Canonical SMILES |
C1CCC(CC1)COC2=CC=CC(=C2)C(CCN)O
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| InChI |
1S/C16H25NO2/c17-10-9-16(18)14-7-4-8-15(11-14)19-12-13-5-2-1-3-6-13/h4,7-8,11,13,16,18H,1-3,5-6,9-10,12,17H2/t16-/m1/s1
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| InChIKey |
WJIGGYYSZBWCGC-MRXNPFEDSA-N
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| CAS Number |
CAS 1141777-14-1
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Retinal pigment epithelium protein (RPE65) | Target Info | Inhibitor | [2] |
| BioCyc | The visual cycle I (vertebrates) | |||
| KEGG Pathway | Retinol metabolism | |||
| Pathwhiz Pathway | Retinol Metabolism | |||
| Pathway Interaction Database | Visual signal transduction: Cones | |||
| Visual signal transduction: Rods | ||||
| Reactome | The canonical retinoid cycle in rods (twilight vision) | |||
| WikiPathways | Vitamin A and Carotenoid Metabolism | |||
| Visual phototransduction | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01802866) Safety and Efficacy Assessment Treatment Trials of Emixustat Hydrochloride. U.S. National Institutes of Health. | |||
| REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
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