Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0GY0O
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| Former ID |
DIB002345
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| Drug Name |
BAY-X-7195
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| Synonyms |
BAY-X-7195; UGWPB2QIT9; UNII-UGWPB2QIT9; BAY X-7195; BAY X 7195; AC1O5X0Q; 143538-27-6; SCHEMBL156423; CHEMBL314115; 4-[(Z,4S)-7-hydroxy-7-oxo-1-[4-(4-phenoxybutoxy)phenyl]hept-2-en-4-yl]sulfanylbenzoic acid
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| Drug Type |
Small molecular drug
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| Indication | Asthma [ICD-11: CA23; ICD-10: J45, J45.8; ICD-9: 493] | Phase 2 | [1] | |
| Company |
Bayer AG
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| Structure |
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Download2D MOL |
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| Formula |
C30H32O6S
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| Canonical SMILES |
C1=CC=C(C=C1)OCCCCOC2=CC=C(C=C2)CC=CC(CCC(=O)O)SC3=CC=C(C=C3)C(=O)O
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| InChI |
1S/C30H32O6S/c31-29(32)20-19-27(37-28-17-13-24(14-18-28)30(33)34)10-6-7-23-11-15-26(16-12-23)36-22-5-4-21-35-25-8-2-1-3-9-25/h1-3,6,8-18,27H,4-5,7,19-22H2,(H,31,32)(H,33,34)/b10-6-/t27-/m1/s1
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| InChIKey |
MHKAEITVUICXRN-BPGQXAFDSA-N
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| CAS Number |
CAS 143538-27-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Leukotriene CysLT1 receptor (CYSLTR1) | Target Info | Modulator | [2] |
| Leukotriene CysLT2 receptor (CYSLTR2) | Target Info | Modulator | [2] | |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| IL4 Signaling Pathway | ||||
| IL3 Signaling Pathway | ||||
| Pathway Interaction Database | Endothelins | |||
| Reactome | Leukotriene receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003794) | |||
| REF 2 | The effect of a novel leukotriene C4/D4 antagonist, BAY-x-7195, on experimental allergic reactions. Prostaglandins. 1995 Nov-Dec;50(5-6):269-85. | |||
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