Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0GZ7B
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| Former ID |
DNC000170
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| Drug Name |
AG490
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| Synonyms |
(E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide; 133550-30-8; AG-490; Tyrphostin B42; Tyrphostin AG 490; AG 490; (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide; Tyrphostin AG490; tyrphostin AG-490; AG-490 (Tyrphostin B42); alpha-Cyano-(3,4-dihydroxy)-N-benzylcinnamide; N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide; 134036-52-5; (2E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide; CHEMBL56543; (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide; (2E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-(PHENYLMETHYL)-2-PROPENAMIDE; SMR001230665
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| Drug Type |
Small molecular drug
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| Indication | Multiple myeloma [ICD-11: 2A83; ICD-10: C90] | Terminated | [1], [2] | |
| Renal transplantation [ICD-11: NE84] | Terminated | [1], [2] | ||
| Structure |
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Download2D MOL |
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| Formula |
C17H14N2O3
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| Canonical SMILES |
C1=CC=C(C=C1)CNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N
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| InChI |
1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+
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| InChIKey |
TUCIOBMMDDOEMM-RIYZIHGNSA-N
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| CAS Number |
CAS 133550-30-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
629517, 8033990, 11061045, 11111876, 11113487, 14849288, 17405722, 24278732, 26751707, 26751708, 26759681, 39301404, 47290860, 47588720, 47810470, 47810471, 47885126, 48110172, 50104393, 50104394, 50104395, 53778272, 53789794, 56314167, 56463448, 57361285, 71751762, 78726229, 80953720, 85231253, 85787739, 88804259, 90341519, 92303385, 92309812, 99300726, 99302244, 99302805, 99436917, 103244043, 104051609, 113910669, 118311117, 124658725, 124757030, 124799933, 124881621, 124881622, 124881623, 124881624
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| ChEBI ID |
CHEBI:131968
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5916). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006610) | |||
| REF 3 | Jak2 tyrosine kinase mediates oxidative stress-induced apoptosis in vascular smooth muscle cells. J Biol Chem. 2004 Aug 13;279(33):34547-52. | |||
| REF 4 | The JAK2 inhibitor AG490 predominantly abrogates the growth of human B-precursor leukemic cells with 11q23 translocation or Philadelphia chromosome. Leukemia. 2001 Nov;15(11):1758-68. | |||
| REF 5 | Immunotherapy for De Novo renal transplantation: what's in the pipeline Drugs. 2006;66(13):1665-84. | |||
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