Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0H2GT
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| Drug Name |
Pyrrole derivative 3
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| Synonyms |
PMID26161824-Compound-6
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| Drug Type |
Small molecular drug
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| Indication | Obesity [ICD-11: 5B81; ICD-10: E66; ICD-9: 278] | Patented | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C32H31ClN2O4S
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| Canonical SMILES |
C1CN(CCC1(C2=CC=CC=C2)C(=O)N)C(=O)C3=CC(=C(S3)C4=CC=CC=C4Cl)C5=CC=C(C=C5)OCCCO
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| InChI |
1S/C32H31ClN2O4S/c33-27-10-5-4-9-25(27)29-26(22-11-13-24(14-12-22)39-20-6-19-36)21-28(40-29)30(37)35-17-15-32(16-18-35,31(34)38)23-7-2-1-3-8-23/h1-5,7-14,21,36H,6,15-20H2,(H2,34,38)
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| InChIKey |
MWPKIBLLWUZVNJ-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cannabinoid receptor 1 (CB1) | Target Info | Antagonist | [1] |
| Target's Patent Info | Cannabinoid receptor 1 (CB1) | Target's Patent Info | [1] | |
| KEGG Pathway | Rap1 signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Retrograde endocannabinoid signaling | ||||
| Panther Pathway | Endogenous cannabinoid signaling | |||
| Pathway Interaction Database | N-cadherin signaling events | |||
| Reactome | Class A/1 (Rhodopsin-like receptors) | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Small Ligand GPCRs | ||||
| BDNF signaling pathway | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. | |||
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