Drug Information
Drug General Information | Top | |||
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Drug ID |
D0H2KD
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Former ID |
DNC005887
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Drug Name |
(1H-indol-2-yl)(piperazin-1-yl)methanone
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Synonyms |
2-(piperazin-1-ylcarbonyl)-1H-indole; 136818-95-6; CHEMBL129660; 1H-indol-2-yl-1-piperazinyl-Methanone; 1H-indol-2-yl(piperazin-1-yl)methanone; 2-(piperazine-1-carbonyl)-1H-indole; (1H-Indol-2-yl)-piperazin-1-yl-methanone; piperazoylindole; AC1LJDZ7; (1H-indol-2-yl)(piperazin-1-yl)methanone; Oprea1_711133; SCHEMBL2679610; DTXSID30358889; MolPort-002-566-226; FIVCRRVYLAXYFC-UHFFFAOYSA-N; ZINC509902; ALBB-016237; STL484224; BDBM50133002; 4012AD; AKOS000210389; MCULE-2536499366; NS-02944; Piperazine, 1-(1H-indol-2-ylcarbonyl)-
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C13H15N3O
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Canonical SMILES |
C1CN(CCN1)C(=O)C2=CC3=CC=CC=C3N2
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InChI |
1S/C13H15N3O/c17-13(16-7-5-14-6-8-16)12-9-10-3-1-2-4-11(10)15-12/h1-4,9,14-15H,5-8H2
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InChIKey |
FIVCRRVYLAXYFC-UHFFFAOYSA-N
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CAS Number |
CAS 136818-95-6
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Histamine H3 receptor (H3R) | Target Info | Inhibitor | [1] |
Histamine H4 receptor (H4R) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Reactome | Histamine receptors | |||
G alpha (i) signalling events | ||||
WikiPathways | GPCR ligand binding | |||
GPCR downstream signaling | ||||
GPCRs, Other | ||||
Monoamine Transport | ||||
GPCRs, Class A Rhodopsin-like |
References | Top | |||
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REF 1 | Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists. J Med Chem. 2005 Dec 29;48(26):8289-98. |
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