Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0H2VY
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| Former ID |
DNC003509
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| Drug Name |
8-benzyl-9H-purine-2,6-diamine
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| Synonyms |
8-Benzyl-9H-purine-2,6-diamine; CHEMBL102303; 9H-Purine-2,6-diamine, 8-(phenylmethyl)-; AC1L9X4P; SCHEMBL3923325; 8-benzyl-7H-purine-2,6-diamine; BDBM50059941
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C12H12N6
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| Canonical SMILES |
C1=CC=C(C=C1)CC2=NC3=NC(=NC(=C3N2)N)N
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| InChI |
1S/C12H12N6/c13-10-9-11(18-12(14)17-10)16-8(15-9)6-7-4-2-1-3-5-7/h1-5H,6H2,(H5,13,14,15,16,17,18)
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| InChIKey |
AFWYNOWVYKOMGZ-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Polypeptide deformylase (PDF) | Target Info | Inhibitor | [1] |
| Pathwhiz Pathway | Folate Metabolism | |||
| Pterine Biosynthesis | ||||
| Reactome | E2F mediated regulation of DNA replication | |||
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | ||||
| Metabolism of folate and pterines | ||||
| G1/S-Specific Transcription | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | CoMFA analysis of tgDHFR and rlDHFR based on antifolates with 6-5 fused ring system using the all-orientation search (AOS) routine and a modified c... Bioorg Med Chem. 2010 Feb 15;18(4):1684-701. | |||
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