Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0H4IU
|
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| Former ID |
DCL000820
|
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| Drug Name |
GPI-16072
|
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| Drug Type |
Small molecular drug
|
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| Indication | Neuropathic pain [ICD-11: 8E43.0] | Phase 1 | [1] | |
| Therapeutic Class |
Analgesics
|
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| Company |
MGI Pharma
|
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| Structure |
 |
Download2D MOL |
||
| Formula |
C6H11O7P
|
|||
| Canonical SMILES |
C(CC(=O)O)C(CP(O)OO)C(=O)O
|
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| InChI |
1S/C6H11O7P/c7-5(8)2-1-4(6(9)10)3-14(12)13-11/h4,11-12H,1-3H2,(H,7,8)(H,9,10)
|
|||
| InChIKey |
HKANXFJUBKMWSW-UHFFFAOYSA-N
|
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glutamate carboxypeptidase II (GCPII) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Alanine, aspartate and glutamate metabolism | |||
| Metabolic pathways | ||||
| Vitamin digestion and absorption | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| TNFalpha Signaling Pathway | ||||
| Reactome | Amino acid synthesis and interconversion (transamination) | |||
| WikiPathways | One Carbon Metabolism | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52. | |||
| REF 2 | Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. | |||
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