Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0H4JM
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| Former ID |
DAP000087
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| Drug Name |
Yohimbine
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| Synonyms |
APHRODINE; Actibine; Aphrodyne; Aphrosol; Corynine; Johimbin; Quebrachin; Quebrachine; Thybine; Yocon; Yohimar; Yohimbin; Yohimex; Yoman; Yovital; Dayto himbin; Yohimbic acid methyl ester; Baron-X; Trans-Quinolizidine yohimbine; Yohimbine (DCF); Methyl 17alpha-hydroxyyohimban-16alpha-carboxylate; Yohimbol-16alpha-carboxylic acid, methyl ester (6CI); Benz[g]indolo[2,3-a]quinolizine, yohimban-16-carboxylic acid deriv.; Methyl (16alpha,17alpha)-17-hydroxyyohimban-16-carboxylate; Yohimban-16alpha-carboxylic acid, 17alpha-hydroxy-, methyl ester (8CI); Yohimban-16-alpha-carboxylic acid, 17-alpha-hydroxy-, methyl ester; Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16alpha,17alpha)-(9CI); Yohimban-16-.alpha.-carboxylic acid, 17-.alpha.-hydroxy-, methyl ester; (+)-Yohimbin; (+)-Yohimbine; (16alpha,17alpha)-17-Hydroxy-yohimban-16-carboxylic acid methyl ester; (16alpha,17alpha)-17-hydroxyyohimban-16-carboxylic acid methyl ester; 17-Hydroxy-yohimbane-16-carboxylic acid methyl ester; 17-Hydroxyyohimban-16-carboxylic acid methyl ester; 17alpha-hydroxyyohimban-16alpha-carboxylic acid methyl ester; 2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-indolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylic acid methyl ester
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| Drug Type |
Small molecular drug
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| Indication | Erectile dysfunction [ICD-11: HA01.1; ICD-10: N48.4; ICD-9: 302.72, 607.84] | Approved | [1], [2] | |
| Therapeutic Class |
Mydriatics
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| Company |
Palisades Pharmaceuticals Inc
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| Structure |
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Download2D MOL |
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| Formula |
C21H26N2O3
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| Canonical SMILES |
COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O
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| InChI |
1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1
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| InChIKey |
BLGXFZZNTVWLAY-SCYLSFHTSA-N
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| CAS Number |
CAS 146-48-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
11447, 587676, 605307, 840951, 841871, 7980901, 8156377, 11120335, 11120823, 11121311, 11121803, 11122283, 11362990, 11365552, 11368114, 11371131, 11371132, 11373715, 11376276, 11466612, 11467732, 11486383, 11533345, 14754428, 14852160, 29227596, 46501178, 46504602, 47275218, 47349036, 47573040, 47646243, 47794706, 47869289, 48018552, 48318057, 48393589, 49698567, 50063657, 50104741, 50104742, 56459445, 57325346, 79341239, 81044603, 85787300, 85787958, 90340710, 92308815, 92310154
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| ChEBI ID |
CHEBI:10093
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| SuperDrug ATC ID |
G04BE04
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| SuperDrug CAS ID |
cas=000146485
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Adrenergic receptor Alpha-2 (ADRA2) | Target Info | Antagonist | [2], [3], [4] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 102). | |||
| REF 2 | Interest of alpha2-adrenergic agonists and antagonists in clinical practice: background, facts and perspectives. Curr Top Med Chem. 2007;7(2):187-94. | |||
| REF 3 | Acute neurotoxicity after yohimbine ingestion by a body builder. Clin Toxicol (Phila). 2009 Sep;47(8):827-9. | |||
| REF 4 | Alpha2-adrenergic receptors attenuate secretagogue-induced endocytosis and promote exocytosis of intestinal NHE2 and NHE3. J Pharmacol Exp Ther. 2009 Sep;330(3):818-25. | |||
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