Drug Information
Drug General Information | Top | |||
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Drug ID |
D0H4NR
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Former ID |
DNC008976
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Drug Name |
N-(3,4-Dichlorophenyl)propyl-ETAV
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Synonyms |
N-(3,4-Dichlorophenyl)propyl-ETAV; CHEMBL495100
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C25H36Cl2N4O8
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Canonical SMILES |
CC(C)C(C(=O)O)NC(=O)C(C)NC(=O)C(C(C)O)NC(=O)C(CCC(=O)O)NCCC1=CC(=C(C=C1)Cl)Cl
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InChI |
1S/C25H36Cl2N4O8/c1-12(2)20(25(38)39)30-22(35)13(3)29-24(37)21(14(4)32)31-23(36)18(7-8-19(33)34)28-10-9-15-5-6-16(26)17(27)11-15/h5-6,11-14,18,20-21,28,32H,7-10H2,1-4H3,(H,29,37)(H,30,35)(H,31,36)(H,33,34)(H,38,39)/t13-,14?,18-,20-,21-/m0/s1
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InChIKey |
QVZKLLUMEYWUMT-WHJBMRRRSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Presynaptic density protein 95 (DLG4) | Target Info | Inhibitor | [1] |
KEGG Pathway | Hippo signaling pathway | |||
Glutamatergic synapse | ||||
Huntington's disease | ||||
Cocaine addiction | ||||
Panther Pathway | Huntington disease | |||
Pathway Interaction Database | ErbB4 signaling events | |||
Reactome | Trafficking of AMPA receptors | |||
Unblocking of NMDA receptor, glutamate binding and activation | ||||
CREB phosphorylation through the activation of CaMKII | ||||
Ras activation uopn Ca2+ infux through NMDA receptor | ||||
RHO GTPases activate CIT | ||||
RAF/MAP kinase cascade | ||||
WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||
L1CAM interactions |
References | Top | |||
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REF 1 | Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem. 2008 Oct 23;51(20):6450-9. |
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