Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0H8IH
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| Drug Name |
PMID26609882-Compound-36
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| Drug Type |
Small molecular drug
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| Company |
ARENA PHARMACEUTICALS, INC. SELVEY, Lee, Alani CARLOS, Marlon V. MAFFUID, Paul SHAN, Yun BETTS, William, L., III GIVEN, Deam, Windate, III HART, Ryan, M. SHAO, Zezhi, Jesse
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| Structure |
 |
Download2D MOL |
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| Formula |
C18H15BrF2N4O2
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| Canonical SMILES |
CN1C(=C(C=N1)Br)C2=C(C=CC(=C2)NC(=O)NC3=C(C=C(C=C3)F)F)OC
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| InChI |
1S/C18H15BrF2N4O2/c1-25-17(13(19)9-22-25)12-8-11(4-6-16(12)27-2)23-18(26)24-15-5-3-10(20)7-14(15)21/h3-9H,1-2H3,(H2,23,24,26)
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| InChIKey |
COSPVUFTLGQDQL-UHFFFAOYSA-N
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| CAS Number |
CAS 839713-36-9
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 2A receptor (HTR2A) | Target Info | Antagonist | [1] |
| Target's Patent Info | 5-HT 2A receptor (HTR2A) | Target's Patent Info | [1] | |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Serotonergic synapse | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | 5HT2 type receptor mediated signaling pathway | |||
| Reactome | Serotonin receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Serotonin Receptor 2 and STAT3 Signaling | |||
| Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | ||||
| SIDS Susceptibility Pathways | ||||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106. | |||
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