Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0HD2G
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| Former ID |
DIB020709
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| Drug Name |
phloretin
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| Synonyms |
phloretin; 60-82-2; 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one; Dihydronaringenin; Phloretol; 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone; NSC 407292; UNII-S5J5OE47MK; 1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-; CCRIS 7459; beta-(p-Hydroxyphenyl)phloropropiophenone; 2',4',6'-Trihydroxy-3-(p-hydroxyphenyl)propiophenone; 2',4',6'-Trihydroxy-3-(4-Hydroxyphenyl)propiophenone; EINECS 200-488-7; NSC407292; S5J5OE47MK; beta-(p-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C15H14O5
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| Canonical SMILES |
C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O)O)O)O
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| InChI |
1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2
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| InChIKey |
VGEREEWJJVICBM-UHFFFAOYSA-N
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| CAS Number |
CAS 60-82-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
4036, 477076, 841166, 885022, 3152290, 6900044, 7979953, 8141738, 8144209, 8152940, 11111666, 11111667, 11341604, 11361787, 11364189, 11366751, 11369313, 11372170, 11374941, 11377475, 11484537, 11487189, 11488497, 11490851, 11492986, 11495109, 11537656, 14750659, 17405570, 22425581, 24278652, 24771297, 24887442, 26613299, 26679936, 26725279, 26747651, 26753632, 26759355, 29204475, 29223872, 46500461, 47440053, 47736274, 47736275, 47885227, 47959549, 48334288, 48421899, 49760075
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| ChEBI ID |
CHEBI:17276
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Aquaporin-9 (AQP9) | Target Info | Inhibitor | [2] |
| Chloride channel protein 3 (CLC-3) | Target Info | Blocker (channel blocker) | [3] | |
| Solute carrier family 23 member 1 (SLC23A1) | Target Info | Inhibitor | [4] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4285). | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 696). | |||
| REF 3 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 702). | |||
| REF 4 | A family of mammalian Na+-dependent L-ascorbic acid transporters. Nature. 1999 May 6;399(6731):70-5. | |||
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