Drug Information
Drug General Information | Top | |||
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Drug ID |
D0HE4S
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Former ID |
DNC003548
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Drug Name |
Disulergine
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Synonyms |
Disulergine; UNII-1Q3CYC1YR6; 1Q3CYC1YR6; CHEMBL95067; 59032-40-5; Disulergina; Disulerginum; Sulergin; disulergine[inn]; Disulergine [INN]; Disulerginum [INN-Latin]; Disulergina [INN-Spanish]; Compound 71; SULERGINE; CM 29717; CH 29-717; CH-29717; AC1Q6V4Q; AC1L2AG4; SCHEMBL1841646; BDBM50130260; CH 29717; N,N-Dimethyl-N'-(6-methylergolin-8alpha-yl)sulfamide; N,N-Dimethyl-N'-((8 alpha)-6-methylergolin-8-yl)sulfamide
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C17H24N4O2S
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Canonical SMILES |
CN1CC(CC2C1CC3=CNC4=CC=CC2=C34)NS(=O)(=O)N(C)C
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InChI |
1S/C17H24N4O2S/c1-20(2)24(22,23)19-12-8-14-13-5-4-6-15-17(13)11(9-18-15)7-16(14)21(3)10-12/h4-6,9,12,14,16,18-19H,7-8,10H2,1-3H3/t12-,14+,16+/m0/s1
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InChIKey |
VUEGYUOUAAVYAS-JGGQBBKZSA-N
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CAS Number |
CAS 59032-40-5
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | 5-HT 7 receptor (HTR7) | Target Info | Inhibitor | [1] |
KEGG Pathway | Ras signaling pathway | |||
Calcium signaling pathway | ||||
Neuroactive ligand-receptor interaction | ||||
Serotonergic synapse | ||||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
Pathwhiz Pathway | Excitatory Neural Signalling Through 5-HTR 7 and Serotonin | |||
Reactome | Serotonin receptors | |||
G alpha (s) signalling events | ||||
WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | |||
Monoamine GPCRs | ||||
GPCRs, Class A Rhodopsin-like | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). J Med Chem. 2003 Jul 3;46(14):2795-812. |
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