Drug Information
Drug General Information | Top | |||
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Drug ID |
D0HE7C
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Drug Name |
ORIC-101
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Synonyms |
VNLTWJIWEYPBIF-SXJSTINISA-N; 2222344-98-9
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Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Phase 1 | [1] | |
Company |
ORIC Pharmaceuticals South San Francisco, CA
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Structure |
Download2D MOL |
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Formula |
C34H47NO2
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Canonical SMILES |
CC(C)N(C)C1=CC=C(C=C1)C2CC3(C(CCC3(C#CC(C)(C)C)O)C4C2C5CCC(=O)C=C5CC4)C
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InChI |
1S/C34H47NO2/c1-22(2)35(7)25-11-8-23(9-12-25)29-21-33(6)30(16-17-34(33,37)19-18-32(3,4)5)28-14-10-24-20-26(36)13-15-27(24)31(28)29/h8-9,11-12,20,22,27-31,37H,10,13-17,21H2,1-7H3/t27-,28-,29+,30-,31+,33-,34+/m0/s1
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InChIKey |
VNLTWJIWEYPBIF-KMSLUKAPSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Glucocorticoid receptor messenger RNA (GCR mRNA) | Target Info | Antagonist | [1] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
NetPath Pathway | IL2 Signaling Pathway | |||
TCR Signaling Pathway | ||||
Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | |||
Signaling events mediated by HDAC Class II | ||||
FOXA2 and FOXA3 transcription factor networks | ||||
Glucocorticoid receptor regulatory network | ||||
Regulation of Androgen receptor activity | ||||
AP-1 transcription factor network | ||||
Reactome | BMAL1:CLOCK,NPAS2 activates circadian gene expression | |||
WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | |||
SIDS Susceptibility Pathways | ||||
Endoderm Differentiation | ||||
Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | ||||
Adipogenesis | ||||
Circadian Clock | ||||
Nuclear Receptors |
References | Top | |||
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REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) |
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