Drug Information
Drug General Information | Top | |||
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Drug ID |
D0HK7R
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Former ID |
DIB012734
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Drug Name |
Midafotel
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Synonyms |
EAA-494
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Drug Type |
Small molecular drug
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Indication | Cognitive impairment [ICD-11: 6D71; ICD-10: F06.7] | Discontinued in Phase 3 | [1] | |
Company |
BTG plc
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Structure |
Download2D MOL |
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Formula |
C8H15N2O5P
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Canonical SMILES |
C1CN(CC(N1)C(=O)O)CC=CP(=O)(O)O
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InChI |
1S/C8H15N2O5P/c11-8(12)7-6-10(4-2-9-7)3-1-5-16(13,14)15/h1,5,7,9H,2-4,6H2,(H,11,12)(H2,13,14,15)/b5-1+/t7-/m1/s1
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InChIKey |
VZXMZMJSGLFKQI-ABVWVHJUSA-N
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CAS Number |
CAS 117414-74-1
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | N-methyl-D-aspartate receptor (NMDAR) | Target Info | Modulator | [2] |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002722) | |||
REF 2 | D-CPP-ene (SDZ EAA 494), a potent and competitive N-methyl-D-aspartate (NMDA) antagonist: effect on spontaneous activity and NMDA-induced depolarizations in the rat neocortical slice preparation, compared with other CPP derivatives and MK-801. Neurosci Lett. 1990 Jun 8;113(3):315-21. |
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