Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0HO2T
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| Former ID |
DCL000479
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| Drug Name |
AZD7325
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| Synonyms |
AZD-7325; UNII-KNM216XOUH; KNM216XOUH; CHEMBL1783282; 942437-37-8; AZD7325; KYDURMHFWXCKMW-UHFFFAOYSA-N; SCHEMBL1962584; GTPL7712; AZD 7325; BDBM50418481; SB17497; 4-amino-8-(2-fluoro-6-methoxyphenyl)-N-propylcinnoline-3-carboxamide; 4-Amino-8-(2-fluoro-6-methoxy-phenyl)-N-propylcinnoline-3-carboxamide
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| Drug Type |
Small molecular drug
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| Indication | Anxiety disorder [ICD-11: 6B00-6B0Z; ICD-10: R45.0] | Phase 2 | [1], [2] | |
| Company |
AstraZeneca
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| Structure |
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Download2D MOL
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| Formula |
C19H19FN4O2
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| Canonical SMILES |
CCCNC(=O)C1=NN=C2C(=C1N)C=CC=C2C3=C(C=CC=C3F)OC
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| InChI |
1S/C19H19FN4O2/c1-3-10-22-19(25)18-16(21)12-7-4-6-11(17(12)23-24-18)15-13(20)8-5-9-14(15)26-2/h4-9H,3,10H2,1-2H3,(H2,21,23)(H,22,25)
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| InChIKey |
KYDURMHFWXCKMW-UHFFFAOYSA-N
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| CAS Number |
CAS 942437-37-8
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glutamate receptor AMPA (GRIA) | Target Info | Agonist | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7712). | |||
| REF 2 | ClinicalTrials.gov (NCT00807937) Proof of Concept in Patients With Generalized Anxiety Disorder (GAD)AZD7325. U.S. National Institutes of Health. | |||
| REF 3 | Clinical pipeline report, company report or official report of AstraZeneca (2009). | |||
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