Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0HQ1W
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| Former ID |
DIB011501
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| Drug Name |
SKF-96365
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| Synonyms |
SK-96365; 1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]-1H-imidazole; 1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole; 1-[beta-[3-(4-Methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole; 1-(2-(3-(4-Methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole; AC1L2XSB; SKF-96365 free base; Imidazole-based ligand, 15; KBioSS_000197; KBioGR_000197; BSPBio_001477; SCHEMBL722014; GTPL2441; CHEMBL258502; KBio3_000394; KBio2_000197; KBio3_000393; KBio2_005333; KBio2_002765; CHEBI:91847; BDBM21164
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| Drug Type |
Small molecular drug
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| Indication | Angina pectoris [ICD-11: BA40; ICD-9: 413] | Terminated | [1], [2] | |
| Company |
SmithKline Beecham plc
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| Structure |
 |
Download2D MOL
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| Formula |
C22H27ClN2O3
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| Canonical SMILES |
COC1=CC=C(C=C1)CCCOC(CN2C=CN=C2)C3=CC=C(C=C3)OC.Cl
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| InChI |
1S/C22H26N2O3.ClH/c1-25-20-9-5-18(6-10-20)4-3-15-27-22(16-24-14-13-23-17-24)19-7-11-21(26-2)12-8-19;/h5-14,17,22H,3-4,15-16H2,1-2H3;1H
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| InChIKey |
FWLPKVQUECFKSW-UHFFFAOYSA-N
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| CAS Number |
CAS 130495-35-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
6319097, 10233695, 11120287, 11120775, 11121263, 11121542, 11122022, 11362611, 11365173, 11367735, 11370493, 11370494, 11373336, 11375897, 15052667, 26752097, 26752098, 44434516, 48034870, 48334240, 48334241, 49689237, 50104751, 79562942, 85788250, 92309893, 99300807, 99302325, 103567179, 104373304, 125335472, 128077959, 134345536, 135651058, 139283035, 227010753, 252455617
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| ChEBI ID |
CHEBI:145121
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Calcium channel unspecific (CaC) | Target Info | Modulator | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2441). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000362) | |||
| REF 3 | The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels. Br J Pharmacol. 2010 Jul;160(6):1464-75. | |||
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