Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0I0ZO
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| Former ID |
DIB015781
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| Drug Name |
Anti-CD45 mabs
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| Synonyms |
AHCD45 therapy, Baylor College; YTH-24; YTH-24/54; YTH-25.4; YTH-54.12; Anti-CD45 mAbs (stem cell transplantation/cancer); Anti-CD45 mAbs (stem cell transplantation/cancer), Baylor College
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| Drug Type |
Antibody
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| Indication | Lymphoma [ICD-11: 2A80-2A86; ICD-9: 202.8, 208.9] | Phase 1 | [1] | |
| Company |
Baylor College of Medicine
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Leukocyte common antigen (PTPRC) | Target Info | . | [2] |
| KEGG Pathway | Cell adhesion molecules (CAMs) | |||
| T cell receptor signaling pathway | ||||
| Fc gamma R-mediated phagocytosis | ||||
| Primary immunodeficiency | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| IL2 Signaling Pathway | ||||
| Panther Pathway | B cell activation | |||
| JAK/STAT signaling pathway | ||||
| T cell activation | ||||
| Pathway Interaction Database | BCR signaling pathway | |||
| TCR signaling in naï | ||||
| TCR signaling in naï | ||||
| CXCR4-mediated signaling events | ||||
| Reactome | Phosphorylation of CD3 and TCR zeta chains | |||
| Other semaphorin interactions | ||||
| WikiPathways | Interferon type I signaling pathways | |||
| EPO Receptor Signaling | ||||
| B Cell Receptor Signaling Pathway | ||||
| TCR signaling | ||||
| Semaphorin interactions | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00078546) EBV-Specific CTLs Following CD45 Antibody to Patients With Epstein-Barr Virus (EBV) + Nasopharyngeal Carcinoma (NPC). U.S. National Institutes of Health. | |||
| REF 2 | CD45 monoclonal antibody-mediated cytolysis of human NK and T lymphoma cells. Haematologica. 2006 Jul;91(7):886-94. | |||
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