Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0I3TU
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| Former ID |
DIB006842
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| Drug Name |
MK-7246
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| Synonyms |
IDDBCP261213; IDDBCP271467
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| Drug Type |
Small molecular drug
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| Indication | Respiratory disease [ICD-11: CB40] | Phase 1 | [1] | |
| Company |
Merck & Co Inc
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| Structure |
 |
Download2D MOL |
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| Formula |
C21H21FN2O4S
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| Canonical SMILES |
CN(C1CCC2=C(C3=CC=CC=C3N2C1)CC(=O)O)S(=O)(=O)C4=CC=C(C=C4)F
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| InChI |
1S/C21H21FN2O4S/c1-23(29(27,28)16-9-6-14(22)7-10-16)15-8-11-20-18(12-21(25)26)17-4-2-3-5-19(17)24(20)13-15/h2-7,9-10,15H,8,11-13H2,1H3,(H,25,26)/t15-/m1/s1
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| InChIKey |
JTCAGRAKUAAYDY-OAHLLOKOSA-N
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| CAS Number |
CAS 1218918-62-7
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Prostaglandin D2 receptor 2 (PTGDR2) | Target Info | Modulator | [2] |
| Reactome | Prostanoid ligand receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031315) | |||
| REF 2 | Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases. Bioorg Med Chem Lett. 2011 Jan 1;21(1):288-93. | |||
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