Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0I7IB
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| Former ID |
DCL001100
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| Drug Name |
Sodium butyrate
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| Synonyms |
Butyrate sodium; Sodium butanoate; Sodium propanecarboxylate; OR8783; Butanoic acid, sodium salt; Butyric Acid, Na; Sodium butyrate (USP); Sodium n-butyrate; TPA/BA; Tetradecanoyl phorbol acetate/ sodium butyrate; Butanoic acid, sodium salt (1:1); Tetradecanoyl phorbol acetate (TPA)/ sodium butyrate (BA)
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| Drug Type |
Small molecular drug
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| Indication | Acute myeloid leukaemia [ICD-11: 2A60] | Phase 2 | [1] | |
| Refractory sickle cell ulcers [ICD-11: 3A51; ICD-10: D57, D57.8] | Phase 2 | [1] | ||
| Company |
Allerderm
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| Structure |
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Download2D MOL |
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| Formula |
C4H7NaO2
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| Canonical SMILES |
CCCC(=O)[O-].[Na+]
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| InChI |
1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1
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| InChIKey |
MFBOGIVSZKQAPD-UHFFFAOYSA-M
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| CAS Number |
CAS 156-54-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3140473, 7772599, 8137204, 8600423, 10509278, 12014931, 15297044, 24858121, 24891873, 26759539, 29227696, 49898106, 56311077, 56311464, 56312142, 56312587, 56313371, 56314083, 57357512, 80709488, 80709489, 84942898, 85736426, 87559080, 88813254, 96021279, 96025681, 99374859, 103256603, 103849246, 104253446, 107598695, 113834572, 117375108, 117687779, 118052709, 124757572, 125164376, 125333742, 125364413, 126688146, 127331465, 127331466, 127331467, 127331468, 127331469, 127331470, 127331471, 134974438, 135610560
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| ChEBI ID |
CHEBI:64103
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| References | Top | |||
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| REF 1 | The enhancement of phase 2 enzyme activities by sodium butyrate in normal intestinal epithelial cells is associated with Nrf2 and p53. Mol Cell Biochem. 2012 Nov;370(1-2):7-14. | |||
| REF 2 | Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov. 2006 Sep;5(9):769-84. | |||
| REF 3 | Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteoclasts but not into macrophages. Blood. 2003 May 1;101(9):3451-9. | |||
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