Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0IC1N
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| Former ID |
DNC007962
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| Drug Name |
(-)-hydroxycitrate
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| Synonyms |
Garcinia acid; 3-c-carboxy-2-deoxy-d-erythro-pentaric acid; CHEMBL118715; UNII-8W94T9026R; (1S,2S)-1,2-dihydroxypropane-1,2,3-tricarboxylic acid; 8W94T9026R; Super CitriMax HCA 600SXS; 4373-35-7; (-)-Hydroxycitrate; 27750-10-3; 7A3; Citric acid, 2-hydroxy-, (-)-; AC1Q5QYE; AC1L4H7S; (2S,3S)-3-Carboxy-2,3-dihydroxy-pentanedioic acid; SCHEMBL6773065; DTXSID20276669; ZINC1656422; BDBM50036210; LMFA01050511; AJ-28889; D-erythro-Pentaric acid,
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C6H8O8
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| Canonical SMILES |
C(C(=O)O)C(C(C(=O)O)O)(C(=O)O)O
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| InChI |
1S/C6H8O8/c7-2(8)1-6(14,5(12)13)3(9)4(10)11/h3,9,14H,1H2,(H,7,8)(H,10,11)(H,12,13)/t3-,6+/m1/s1
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| InChIKey |
ZMJBYMUCKBYSCP-CVYQJGLWSA-N
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| CAS Number |
CAS 27750-10-3
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:165420
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | ATP-citrate synthase (ACLY) | Target Info | Inhibitor | [1], [2] |
| BioCyc | Acetyl-CoA biosynthesis from citrate | |||
| KEGG Pathway | Citrate cycle (TCA cycle) | |||
| Metabolic pathways | ||||
| Biosynthesis of antibiotics | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| Pathwhiz Pathway | Transfer of Acetyl Groups into Mitochondria | |||
| Reactome | ChREBP activates metabolic gene expression | |||
| Fatty Acyl-CoA Biosynthesis | ||||
| WikiPathways | Fatty Acid Biosynthesis | |||
| TCA Cycle and PDHc | ||||
| Butyrate-induced histone acetylation | ||||
| SREBP signalling | ||||
| Integration of energy metabolism | ||||
| Fatty acid, triacylglycerol, and ketone body metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 2-hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3208-11. | |||
| REF 2 | Synthesis of novel thiol-containing citric acid analogues. Kinetic evaluation of these and other potential active-site-directed and mechanism-based... J Med Chem. 1995 Feb 3;38(3):537-43. | |||
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