Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0IK4V
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| Former ID |
DNC011348
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| Drug Name |
GNF-PF-5134
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| Synonyms |
GNF-Pf-5134; SMR000176391; MLS000567447; 1-ethyl-2,3-dimethyl-2-phenylbenzimidazole; 1-Ethyl-2,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzoimidazole; AC1MK4BC; Oprea1_386360; Oprea1_275132; CHEMBL602969; cid_3124417; BDBM34775; MolPort-001-953-343; HMS2514O12; 1-ethyl-2,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzimidazole; AKOS030484368; AKOS000562909; MCULE-9973053606; BAS 01044600; 1-ethyl-2,3-dimethyl-2-phenyl-benzimidazole
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C17H20N2
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| Canonical SMILES |
CCN1C2=CC=CC=C2N(C1(C)C3=CC=CC=C3)C
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| InChI |
1S/C17H20N2/c1-4-19-16-13-9-8-12-15(16)18(3)17(19,2)14-10-6-5-7-11-14/h5-13H,4H2,1-3H3
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| InChIKey |
QWPMTQMHWWDYRA-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Candida Mannose-6-phosphate isomerase (Candi PMI1) | Target Info | Inhibitor | [1] |
| Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | PI3K-Akt signaling pathway | |||
| MicroRNAs in cancer | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | Apoptosis signaling pathway | |||
| CCKR signaling map ST | ||||
| Pathway Interaction Database | E2F transcription factor network | |||
| Direct p53 effectors | ||||
| IL6-mediated signaling events | ||||
| HIF-1-alpha transcription factor network | ||||
| WikiPathways | Apoptosis | |||
| miR-targeted genes in muscle cell - TarBase | ||||
| miR-targeted genes in lymphocytes - TarBase | ||||
| miR-targeted genes in leukocytes - TarBase | ||||
| Apoptosis Modulation and Signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. | |||
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