Drug Information
Drug General Information | Top | |||
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Drug ID |
D0IZ9O
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Former ID |
DNC008414
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Drug Name |
4-dehydroxyriccardin C
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Synonyms |
4-dehydroxyriccardin C; Riccardin C derivative, 20d; CHEMBL411246; BDBM23851; 2',4-(Ethylene-1,4-phenylene-oxy-1,3-phenylene-ethylene)-1,1'-biphenyl-2,4'-diol
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C28H24O3
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Canonical SMILES |
C1CC2=C(C=CC(=C2)O)C3=C(C=C(CCC4=CC(=CC=C4)OC5=CC=C1C=C5)C=C3)O
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InChI |
1S/C28H24O3/c29-23-11-15-26-22(18-23)10-6-19-7-12-24(13-8-19)31-25-3-1-2-20(16-25)4-5-21-9-14-27(26)28(30)17-21/h1-3,7-9,11-18,29-30H,4-6,10H2
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InChIKey |
ZCEPVFMKRVLFDX-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Oxysterols receptor LXR-alpha (NR1H3) | Target Info | Inhibitor | [1] |
Oxysterols receptor LXR-beta (NR1H2) | Target Info | Inhibitor | [1] | |
KEGG Pathway | PPAR signaling pathway | |||
Non-alcoholic fatty liver disease (NAFLD) | ||||
Hepatitis C | ||||
Pathway Interaction Database | RXR and RAR heterodimerization with other nuclear receptor | |||
Reactome | Nuclear Receptor transcription pathway | |||
WikiPathways | SREBP signalling | |||
Nuclear Receptors | ||||
Nuclear Receptors in Lipid Metabolism and Toxicity | ||||
Nuclear Receptors Meta-Pathway | ||||
PPAR Alpha Pathway | ||||
Liver X Receptor Pathway | ||||
Adipogenesis | ||||
SREBF and miR33 in cholesterol and lipid homeostasis |
References | Top | |||
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REF 1 | Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. |
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