Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0J4KJ
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| Former ID |
DNC012703
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| Drug Name |
5-p-Tolylsulfanyl-quinazoline-2,4-diamine
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| Synonyms |
5-(4-Tolylthio)-2,4-diaminoquinazoline; 168910-32-5; 5-[(4-METHYLPHENYL)SULFANYL]-2,4-QUINAZOLINEDIAMINE; CHEMBL83547; 5-[(4-methylphenyl)sulfanyl]quinazoline-2,4-diamine; TQ4; Maybridge3_004364; AC1L9JD9; Oprea1_160965; SCHEMBL2126685; BDBM18046; CTK0E5148; DTXSID80332215; MolPort-002-910-071; HMS1443G08; GW578; ZINC172633; HMS3604M19; CCG-44692; AKOS027447345; MCULE-8600056307; DB04306; IDI1_015751; 5-(p-Tolylthio)quinazoline-2,4-diamine; RT-010103; 5-(p-tolylsulfanyl)quinazoline-2,4-diamine; FT-0675290
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C15H14N4S
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| Canonical SMILES |
CC1=CC=C(C=C1)SC2=CC=CC3=C2C(=NC(=N3)N)N
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| InChI |
1S/C15H14N4S/c1-9-5-7-10(8-6-9)20-12-4-2-3-11-13(12)14(16)19-15(17)18-11/h2-8H,1H3,(H4,16,17,18,19)
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| InChIKey |
UOJFGEAPSYQDIP-UHFFFAOYSA-N
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| CAS Number |
CAS 168910-32-5
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Polypeptide deformylase (PDF) | Target Info | Inhibitor | [1] |
| Pathwhiz Pathway | Folate Metabolism | |||
| Pterine Biosynthesis | ||||
| Reactome | E2F mediated regulation of DNA replication | |||
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | ||||
| Metabolism of folate and pterines | ||||
| G1/S-Specific Transcription | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | X-Ray crystal structures of Candida albicans dihydrofolate reductase: high resolution ternary complexes in which the dihydronicotinamide moiety of ... J Med Chem. 2001 Aug 30;44(18):2928-32. | |||
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