Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0J5EZ
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| Former ID |
DNC009089
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| Drug Name |
AM-2S
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| Synonyms |
AM-2S; CHEMBL470194; SCHEMBL13208678; BDBM50278743
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C20H17NO3S
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| Canonical SMILES |
CC1=CC(=S)C(=C(O1)C(=O)NCC2=CC=C(C=C2)C3=CC=CC=C3)O
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| InChI |
1S/C20H17NO3S/c1-13-11-17(25)18(22)19(24-13)20(23)21-12-14-7-9-16(10-8-14)15-5-3-2-4-6-15/h2-11,22H,12H2,1H3,(H,21,23)
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| InChIKey |
ZOMMNLRHGAAUNM-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Matrix metalloproteinase-3 (MMP-3) | Target Info | Inhibitor | [1] |
| KEGG Pathway | TNF signaling pathway | |||
| Transcriptional misregulation in cancer | ||||
| Rheumatoid arthritis | ||||
| NetPath Pathway | IL1 Signaling Pathway | |||
| IL4 Signaling Pathway | ||||
| Panther Pathway | Plasminogen activating cascade | |||
| CCKR signaling map ST | ||||
| Pathway Interaction Database | Posttranslational regulation of adherens junction stability and dissassembly | |||
| p75(NTR)-mediated signaling | ||||
| Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling | ||||
| Reactome | Collagen degradation | |||
| Degradation of the extracellular matrix | ||||
| Activation of Matrix Metalloproteinases | ||||
| Assembly of collagen fibrils and other multimeric structures | ||||
| EGFR Transactivation by Gastrin | ||||
| WikiPathways | Activation of Matrix Metalloproteinases | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Oncostatin M Signaling Pathway | ||||
| Matrix Metalloproteinases | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis of hydroxypyrone- and hydroxythiopyrone-based matrix metalloproteinase inhibitors: developing a structure-activity relationship. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1970-6. | |||
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