Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0J5FK
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| Former ID |
DIB019922
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| Drug Name |
GNE-7915
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| Synonyms |
GNE7915; GNE 7915
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C19H21F4N5O3
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| Canonical SMILES |
CCNC1=NC(=NC=C1C(F)(F)F)NC2=C(C=C(C(=C2)F)C(=O)N3CCOCC3)OC
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| InChI |
1S/C19H21F4N5O3/c1-3-24-16-12(19(21,22)23)10-25-18(27-16)26-14-9-13(20)11(8-15(14)30-2)17(29)28-4-6-31-7-5-28/h8-10H,3-7H2,1-2H3,(H2,24,25,26,27)
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| InChIKey |
XCFLWTZSJYBCPF-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dual specificity protein kinase TTK (MPS1) | Target Info | Inhibitor | [2] |
| Leucine-rich repeat kinase 2 (LRRK2) | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Cell cycle | |||
| NetPath Pathway | IL2 Signaling Pathway | |||
| WikiPathways | Retinoblastoma (RB) in Cancer | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2012 Nov 26;55(22):9416-33. | |||
| REF 2 | Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2014 Feb 13;57(3):921-36. | |||
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