Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0J6GJ
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| Drug Name |
SPI-1005
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| Synonyms |
Ebselen [INN]; Ebselene; Ebselene [French]; Ebseleno; Ebseleno [Spanish]; Ebselenum; Ebselenum [Latin]; Harmokisane; PZ 51; PZ-51; PZ51; RP 60931; SPI-1005; SPI-3005; 2-Phenyl-1,2-benzisoselenazol-3(2H)-one; 2-Phenyl-1,2-benzisoselenazolin-3-one; 2-phenyl-1,2-benzoisoselenazol-3(2H)-one; 2-phenyl-1,2-benzoselenazol-3-one; DR 3305; DR-3305; E 3520
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| Drug Type |
Small molecular drug
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| Indication | Meniere disease [ICD-11: AB31.0; ICD-10: H81] | Phase 2b | [1] | |
| Coronavirus Disease 2019 (COVID-19) [ICD-11: 1D6Y] | Investigative | [2] | ||
| Therapeutic Class |
Antiviral Agents
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| Structure |
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Download2D MOL |
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| Formula |
C13H9NOSe
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| Canonical SMILES |
C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2
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| InChI |
1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H
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| InChIKey |
DYEFUKCXAQOFHX-UHFFFAOYSA-N
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| CAS Number |
CAS 60940-34-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
499808, 613724, 856002, 3151842, 4908335, 8149768, 8152032, 10321966, 11111148, 11111149, 11121407, 11121887, 11336126, 11361365, 11362476, 11365038, 11367600, 11370223, 11370224, 11371858, 11373201, 11373969, 11375762, 11462337, 11466768, 11467888, 11485037, 11486375, 11489257, 11490615, 11492260, 12013066, 14848495, 17405104, 24278417, 26679934, 26751591, 26758640, 29222336, 46386980, 47216849, 47365276, 47515388, 47662368, 47736572, 47810834, 47885488, 47885489, 48259323, 48259324
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| ChEBI ID |
CHEBI:77543
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | COVID-19 papain-like proteinase (PL-PRO) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Sound Pharmaceuticals announces positive topline results from the SPI-1005 Phase 2b Meniere's Disease clinical trial. Jun 25, 2019 | |||
| REF 2 | Structure of Mpro from COVID-19 virus and discovery of its inhibitors. Nature. 2020 Apr 9. | |||
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