Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0J8RM
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| Former ID |
DIB016300
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| Drug Name |
Posatirelin
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| Synonyms |
Esotirelin; Pyladox; RGH-2202
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| Drug Type |
Small molecular drug
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| Indication | Neurodegenerative disorder [ICD-11: 8A20-8A23] | Discontinued in Phase 3 | [1] | |
| Company |
Gedeon Richter Ltd
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| Structure |
 |
Download2D MOL |
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| Formula |
C17H28N4O4
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| Canonical SMILES |
CC(C)CC(C(=O)N1CCCC1C(=O)N)NC(=O)C2CCCC(=O)N2
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| InChI |
1S/C17H28N4O4/c1-10(2)9-12(17(25)21-8-4-6-13(21)15(18)23)20-16(24)11-5-3-7-14(22)19-11/h10-13H,3-9H2,1-2H3,(H2,18,23)(H,19,22)(H,20,24)/t11-,12-,13-/m0/s1
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| InChIKey |
DPNGIIPSQYKWQA-AVGNSLFASA-N
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| CAS Number |
CAS 78664-73-0
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:135486
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Thyrotropin-releasing hormone receptor (TRHR) | Target Info | Modulator | [2] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Panther Pathway | Thyrotropin-releasing hormone receptor signaling pathway | |||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005568) | |||
| REF 2 | TRH analogs at Gedeon Richter Ltd.: highlights of experimental and clinical efficacy of posatirelin. Acta Pharm Hung. 2002;72(1):62-8. | |||
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