Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0J8RR
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| Former ID |
DCL000773
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| Drug Name |
Dextromethorphan+quinidine
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| Synonyms |
Dextromethorphan hydrobromide monohydrate; 6700-34-1; Dextromethorphan hydrobromide; Methorate; Drixoral Cough; PediaCare 1; Dextromethorphan hydrobromide hydrate; Dextromethorphan (hydrobromide hydrate); Hold; St. Joseph Cough Syrup; Chloraseptic DM; UNII-9D2RTI9KYH; Romilar; Tylenol Cough Liquid; Endotussin-NN Pediatric; Robitussin Cough Calmers; Robitussin Pediatric Cough; 9D2RTI9KYH; Dextromethorphan hydrobromide OROS Tablets; Drixoral Cough & Sore Throat; Robitussin Maximum Strength Cough
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| Drug Type |
Small molecular drug
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| Indication | Diabetic neuropathy [ICD-11: 8C0Z] | Phase 2 | [1] | |
| Company |
Avanir
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| Structure |
 |
Download2D MOL |
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| Formula |
C18H28BrNO2
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| Canonical SMILES |
CN1CCC23CCCCC2C1CC4=C3C=C(C=C4)OC.O.Br
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| InChI |
1S/C18H25NO.BrH.H2O/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18;;/h6-7,12,15,17H,3-5,8-11H2,1-2H3;1H;1H2/t15-,17+,18+;;/m1../s1
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| InChIKey |
STTADZBLEUMJRG-IKNOHUQMSA-N
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| CAS Number |
CAS 6700-34-1
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:4471
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| ADReCS Drug ID | BADD_D00639 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Aromatase (CYP19A1) | Target Info | Inhibitor | [2] |
| N-methyl-D-aspartate receptor (NMDAR) | Target Info | Antagonist | [2] | |
| BioCyc | Superpathway of steroid hormone biosynthesis | |||
| Estradiol biosynthesis II | ||||
| Estradiol biosynthesis I | ||||
| KEGG Pathway | Steroid hormone biosynthesis | |||
| Metabolic pathways | ||||
| Ovarian steroidogenesis | ||||
| NetPath Pathway | FSH Signaling Pathway | |||
| Panther Pathway | Androgen/estrogene/progesterone biosynthesis | |||
| Pathwhiz Pathway | Androgen and Estrogen Metabolism | |||
| Reactome | Endogenous sterols | |||
| WikiPathways | Metapathway biotransformation | |||
| Tryptophan metabolism | ||||
| Oxidation by Cytochrome P450 | ||||
| Ovarian Infertility Genes | ||||
| Metabolism of steroid hormones and vitamin D | ||||
| FSH signaling pathway | ||||
| Integrated Breast Cancer Pathway | ||||
| Phase 1 - Functionalization of compounds | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Dextromethorphan/quinidine: AVP 923, dextromethorphan/cytochrome P450-2D6 inhibitor, quinidine/dextromethorphan. Drugs R D. 2005;6(3):174-7. | |||
| REF 2 | Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26. | |||
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