Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0JA7V
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| Former ID |
DIB008468
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| Drug Name |
PRX-105
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| Synonyms |
Acetylcholinesterase (poison intoxication, ProCellEx), Protalix/Hebrew University of Jerusalem; Acetylcholinesterase (poison intoxication, plant cell-expression), Protalix/Hebrew University of Jerusalem
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| Indication | Poison intoxication [ICD-11: NE6Z; ICD-10: T88.7] | Phase 1 | [1] | |
| Company |
Hebrew University of Jerusalem
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Acetylcholinesterase (AChE) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Glycerophospholipid metabolism | |||
| Cholinergic synapse | ||||
| Panther Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |||
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway | ||||
| Nicotinic acetylcholine receptor signaling pathway | ||||
| Pathwhiz Pathway | Phospholipid Biosynthesis | |||
| Pathway Interaction Database | ATF-2 transcription factor network | |||
| WikiPathways | Monoamine Transport | |||
| Biogenic Amine Synthesis | ||||
| Acetylcholine Synthesis | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01093859) An Exploratory Phase 1 Microdose Study of PRX-105. U.S. National Institutes of Health. | |||
| REF 2 | Preclinical and first-in-human evaluation of PRX-105, a PEGylated, plant-derived, recombinant human acetylcholinesterase-R. Toxicol Appl Pharmacol. 2015 Sep 15;287(3):202-9. | |||
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