Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0JV2P
|
|||
| Former ID |
DIB019031
|
|||
| Drug Name |
BTP2
|
|||
| Synonyms |
YM-58483
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
|
||
| Formula |
C15H9F6N5OS
|
|||
| Canonical SMILES |
CC1=C(SN=N1)C(=O)NC2=CC=C(C=C2)N3C(=CC(=N3)C(F)(F)F)C(F)(F)F
|
|||
| InChI |
1S/C15H9F6N5OS/c1-7-12(28-25-23-7)13(27)22-8-2-4-9(5-3-8)26-11(15(19,20)21)6-10(24-26)14(16,17)18/h2-6H,1H3,(H,22,27)
|
|||
| InChIKey |
XPRZIORDEVHURQ-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 223499-30-7
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
3164889, 5597343, 8151638, 11394760, 12054562, 14807025, 26536396, 26758342, 29221619, 48334613, 50735545, 92272042, 103317256, 104300638, 123220366, 124652464, 125333805, 129723246, 135650028, 139426324, 162249921, 163124766, 163688491, 172890466, 204377153, 226971520, 241053694, 241376719, 252157654, 252450579, 252457328
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Long transient receptor potential channel 4 (TRPM4) | Target Info | Activator | [2] |
| Short transient receptor potential channel 3 (TRPC3) | Target Info | Blocker (channel blocker) | [3] | |
| Short transient receptor potential channel 5 (TRPC5) | Target Info | Blocker (channel blocker) | [4] | |
| Panther Pathway | Alzheimer disease-presenilin pathway | |||
| Pathway Interaction Database | Trk receptor signaling mediated by PI3K and PLC-gamma | |||
| Reactome | Effects of PIP2 hydrolysis | |||
| TRP channels | ||||
| Role of second messengers in netrin-1 signaling | ||||
| WikiPathways | Platelet homeostasis | |||
| Netrin-1 signaling | ||||
| GPCR downstream signaling | ||||
| Effects of PIP2 hydrolysis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2438). | |||
| REF 2 | A pyrazole derivative potently inhibits lymphocyte Ca2+ influx and cytokine production by facilitating transient receptor potential melastatin 4 ch... Mol Pharmacol. 2006 Apr;69(4):1413-20. | |||
| REF 3 | A functional link between store-operated and TRPC channels revealed by the 3,5-bis(trifluoromethyl)pyrazole derivative, BTP2. J Biol Chem. 2005 Mar 25;280(12):10997-1006. | |||
| REF 4 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 490). | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.