Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0JY2K
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| Former ID |
DIB014038
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| Drug Name |
NS-1643
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| Synonyms |
HERG potassium channel openers (arrhythmia); NS-3623; NS-373; HERG potassium channel openers (arrhythmia), NeuroSearch; I(Kr) agonists (arrhythmia), NeuroSearch; Rapid delayed-rectifier current activators (acquired long QT syndrome), NeruoSearch
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| Drug Type |
Small molecular drug
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| Indication | Heart arrhythmia [ICD-11: BC65; ICD-10: I49, I49.8] | Investigative | [1] | |
| Company |
NeuroSearch A/S
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| Structure |
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Download2D MOL |
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| Formula |
C15H10F6N2O3
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| Canonical SMILES |
C1=CC(=C(C=C1C(F)(F)F)NC(=O)NC2=C(C=CC(=C2)C(F)(F)F)O)O
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| InChI |
1S/C15H10F6N2O3/c16-14(17,18)7-1-3-11(24)9(5-7)22-13(26)23-10-6-8(15(19,20)21)2-4-12(10)25/h1-6,24-25H,(H2,22,23,26)
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| InChIKey |
NJFVQMRYJZHGME-UHFFFAOYSA-N
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| CAS Number |
CAS 448895-37-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
15173214, 22573400, 24897438, 29217596, 40267360, 57374332, 78106763, 135650743, 135698605, 137034138, 160839545, 162119371, 162248127, 162525235, 163402449, 163846304, 170474670, 170558902, 189614623, 198960277, 204425702, 223370023, 223397698, 223573615, 227670517, 242313646, 248536620, 252156985, 252262372, 252304534, 252553002
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Voltage-gated potassium channel Kv11.1 (KCNH2) | Target Info | Opener | [2] |
| Pathwhiz Pathway | Muscle/Heart Contraction | |||
| Reactome | Voltage gated Potassium channels | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Hematopoietic Stem Cell Differentiation | ||||
| Potassium Channels | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7660). | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 572). | |||
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