Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0K0ZX
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| Drug Name |
Heteroaryl-pyrazole derivative 3
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| Synonyms |
PMID25435285-Compound-75
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| Drug Type |
Small molecular drug
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| Structure |
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Download2D MOL |
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| Formula |
C21H17F4N5O3S
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| Canonical SMILES |
C1=CC(=CC(=C1)S(=O)(=O)N)C2=NOC(=N2)C3=C(N(N=C3)CF)CCC4=CC=C(C=C4)C(F)(F)F
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| InChI |
1S/C21H17F4N5O3S/c22-12-30-18(9-6-13-4-7-15(8-5-13)21(23,24)25)17(11-27-30)20-28-19(29-33-20)14-2-1-3-16(10-14)34(26,31)32/h1-5,7-8,10-11H,6,9,12H2,(H2,26,31,32)
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| InChIKey |
ZBFNZSWRIVRSIR-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Metabotropic glutamate receptor 2 (mGluR2) | Target Info | Antagonist | [1] |
| Target's Patent Info | Metabotropic glutamate receptor 2 (mGluR2) | Target's Patent Info | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Glutamatergic synapse | ||||
| Cocaine addiction | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Ionotropic glutamate receptor pathway | ||||
| Metabotropic glutamate receptor group II pathway | ||||
| Reactome | G alpha (i) signalling events | |||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. | |||
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