Drug Information
Drug General Information | Top | |||
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Drug ID |
D0K1AF
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Former ID |
DIB002124
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Drug Name |
A-74273
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Synonyms |
A-74723
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Drug Type |
Small molecular drug
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Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Terminated | [1] | |
Company |
Abbott Laboratories
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Structure |
Download2D MOL |
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Formula |
C44H74N4O8
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Canonical SMILES |
CCCCC(C(=O)NC(CC1CCCCC1)C(CC(C(C)C)C(=O)NCCCN2CCOCC2)O)OC(CC3=CC=CC=C3)C(=O)N4CCC(CC4)OCOC
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InChI |
1S/C44H74N4O8/c1-5-6-18-40(56-41(30-35-16-11-8-12-17-35)44(52)48-23-19-36(20-24-48)55-32-53-4)43(51)46-38(29-34-14-9-7-10-15-34)39(49)31-37(33(2)3)42(50)45-21-13-22-47-25-27-54-28-26-47/h8,11-12,16-17,33-34,36-41,49H,5-7,9-10,13-15,18-32H2,1-4H3,(H,45,50)(H,46,51)/t37?,38?,39?,40-,41-/m0/s1
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InChIKey |
NVMVSIUABPBQIL-UOKFUGOKSA-N
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CAS Number |
CAS 130316-95-9
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Angiotensinogenase renin (REN) | Target Info | Inhibitor | [2] |
KEGG Pathway | Renin-angiotensin system | |||
Pathwhiz Pathway | Angiotensin Metabolism | |||
Reactome | Metabolism of Angiotensinogen to Angiotensins | |||
WikiPathways | ACE Inhibitor Pathway | |||
Metabolism of Angiotensinogen to Angiotensins |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001791) | |||
REF 2 | The orally active renin inhibitor A-74273. In vivo and in vitro morpholine ring metabolism in rats, dogs, and humans. Drug Metab Dispos. 1994 Nov-Dec;22(6):880-8. |
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