Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0K1LJ
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| Former ID |
DIB009878
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| Drug Name |
Ad5-TRAIL
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| Synonyms |
Ad5-TRAIL adenoviral gene therapy (prostate cancer), University of Iowa
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| Indication | Prostate cancer [ICD-11: 2C82.0; ICD-10: C61; ICD-9: 185] | Phase 1 | [1] | |
| Company |
University of Iowa
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | TNF related apoptosis inducing ligand (TNFSF10) | Target Info | Modulator | [2] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| FoxO signaling pathway | ||||
| Apoptosis | ||||
| Natural killer cell mediated cytotoxicity | ||||
| Measles | ||||
| Influenza A | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| IL4 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | ||||
| TNFalpha Signaling Pathway | ||||
| Leptin Signaling Pathway | ||||
| Panther Pathway | Apoptosis signaling pathway | |||
| Pathway Interaction Database | TRAIL signaling pathway | |||
| Caspase Cascade in Apoptosis | ||||
| Reactome | Ligand-dependent caspase activation | |||
| Regulation by c-FLIP | ||||
| RIPK1-mediated regulated necrosis | ||||
| CASP8 activity is inhibited | ||||
| Dimerization of procaspase-8 | ||||
| TRAIL signaling | ||||
| WikiPathways | Apoptosis | |||
| Extrinsic Pathway for Apoptosis | ||||
| Apoptosis Modulation and Signaling | ||||
| TP53 Network | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Phase I trial of Ad5-TRAIL-mediated gene transfer in men with locally-confined prostate cancer prior to planned radical prostatectomy. The Journal of Urology. 04/2008; 179(4):396-396. | |||
| REF 2 | Enhancement of Ad5-TRAIL cytotoxicity against renal cell carcinoma with histone deacetylase inhibitors. Cancer Gene Ther. 2006 Jun;13(6):628-32. | |||
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