Drug Information
Drug General Information | Top | |||
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Drug ID |
D0KD5X
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Drug Name |
Pyrazole derivative 31
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Synonyms |
PMID26161824-Compound-45
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Drug Type |
Small molecular drug
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Indication | Obesity [ICD-11: 5B81; ICD-10: E66; ICD-9: 278] | Patented | [1] | |
Company |
GREEN CROSS CORPORATION LEE, Sung-Han SEO, Hee Jeong LEE, Jinhwa KIM, Min-ah KIM, Jeong Min KANG, Suk Youn AHN, Kwang-Woo LEE, Suk Ho
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Structure |
Download2D MOL |
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Formula |
C27H21Cl3N6O2
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Canonical SMILES |
CC(C)(C)C1=NN=C(O1)C2=NN(C(=C2C(=O)NC3=CC=CC=N3)C4=CC=C(C=C4)Cl)C5=C(C=C(C=C5)Cl)Cl
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InChI |
1S/C27H21Cl3N6O2/c1-27(2,3)26-34-33-25(38-26)22-21(24(37)32-20-6-4-5-13-31-20)23(15-7-9-16(28)10-8-15)36(35-22)19-12-11-17(29)14-18(19)30/h4-14H,1-3H3,(H,31,32,37)
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InChIKey |
UGTKDMCWCRRUHZ-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Cannabinoid receptor 1 (CB1) | Target Info | Antagonist | [1] |
Target's Patent Info | Cannabinoid receptor 1 (CB1) | Target's Patent Info | [1] | |
KEGG Pathway | Rap1 signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Retrograde endocannabinoid signaling | ||||
Panther Pathway | Endogenous cannabinoid signaling | |||
Pathway Interaction Database | N-cadherin signaling events | |||
Reactome | Class A/1 (Rhodopsin-like receptors) | |||
G alpha (i) signalling events | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Small Ligand GPCRs | ||||
BDNF signaling pathway | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | A comprehensive patents review on cannabinoid 1 receptor antagonists as antiobesity agents. Expert Opin Ther Pat. 2015 Oct;25(10):1093-116. |
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