Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0KG3M
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| Former ID |
DNC009869
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| Drug Name |
1-(4-chlorophenylsulfonyl)-4-phenylazepan-4-ol
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| Synonyms |
CHEMBL562534; 1-(4-chlorophenylsulfonyl)-4-phenylazepan-4-ol; SCHEMBL12550078
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C18H20ClNO3S
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| Canonical SMILES |
C1CC(CCN(C1)S(=O)(=O)C2=CC=C(C=C2)Cl)(C3=CC=CC=C3)O
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| InChI |
1S/C18H20ClNO3S/c19-16-7-9-17(10-8-16)24(22,23)20-13-4-11-18(21,12-14-20)15-5-2-1-3-6-15/h1-3,5-10,21H,4,11-14H2
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| InChIKey |
RVUCFBVJACHZFJ-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Steroid hormone biosynthesis | |||
| Metabolism of xenobiotics by cytochrome P450 | ||||
| Metabolic pathways | ||||
| Chemical carcinogenesis | ||||
| NetPath Pathway | IL1 Signaling Pathway | |||
| FSH Signaling Pathway | ||||
| Pathwhiz Pathway | Steroidogenesis | |||
| Reactome | Glucocorticoid biosynthesis | |||
| WikiPathways | Prostaglandin Synthesis and Regulation | |||
| Metabolism of steroid hormones and vitamin D | ||||
| Glucocorticoid & Mineralcorticoid Metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | The discovery of azepane sulfonamides as potent 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4563-5. | |||
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