Drug Information
Drug General Information | Top | |||
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Drug ID |
D0KL3U
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Former ID |
DNCL001841
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Drug Name |
AR9281
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Synonyms |
1-(Adamantane-1-yl)-3-(1-acetylpiperidine-4-yl)urea; UNII-4HA03Q8EZ9; 4HA03Q8EZ9; CHEMBL436774; 1-[(1-Acetylpiperidin-4-yl)-3-adamantan-1-yl]urea; 913548-29-5; Ar9281; AR-9281; Apau (enzyme inhibitor); SCHEMBL654229; 1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea; SCHEMBL18464997; MolPort-023-222-910; HUDQLWBKJOMXSZ-UHFFFAOYSA-N; BDBM100423; BDBM50191854; ZINC36330562; AKOS030231617; J3137087F; US8501783, 1153; 1-(adamant-1-yl)-3-(1-acetylpiperidin-4-yl) urea; N-(1-Acetylpiperidin-4-yl)-N'-(adamant-1-yl) urea; N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea
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Drug Type |
Small molecular drug
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Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Phase 2 | [1] | |
Company |
Ar te Therapeutics
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Structure |
Download2D MOL |
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Formula |
C18H29N3O2
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Canonical SMILES |
CC(=O)N1CCC(CC1)NC(=O)NC23CC4CC(C2)CC(C4)C3
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InChI |
1S/C18H29N3O2/c1-12(22)21-4-2-16(3-5-21)19-17(23)20-18-9-13-6-14(10-18)8-15(7-13)11-18/h13-16H,2-11H2,1H3,(H2,19,20,23)
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InChIKey |
HUDQLWBKJOMXSZ-UHFFFAOYSA-N
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CAS Number |
CAS 913548-29-5
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Soluble epoxide hydrolase (EPHX2) | Target Info | Inhibitor | [2] |
KEGG Pathway | Arachidonic acid metabolism | |||
Metabolic pathways | ||||
Peroxisome | ||||
Pathwhiz Pathway | Arachidonic Acid Metabolism | |||
WikiPathways | Metapathway biotransformation | |||
Arachidonate Epoxygenase / Epoxide Hydrolase | ||||
Arachidonic acid metabolism |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT00847899) Evaluation of Soluble Epoxide Hydrolase (s-EH) Inhibitor in Patients With Mild to Moderate Hypertension and Impaired Glucose Tolerance. U.S. National Institutes of Health. | |||
REF 2 | Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem. 2007 Aug 9;50(16):3825-40. |
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