Drug Information
Drug General Information | Top | |||
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Drug ID |
D0L3SA
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Former ID |
DIB021014
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Drug Name |
T2328
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Synonyms |
T-2328; T 2328
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C26H26FN3O
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Canonical SMILES |
COC1=C(C=C(C=C1)C2=C(C=C(C=C2)C#N)F)CNC3CCCNC3C4=CC=CC=C4
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InChI |
1S/C26H26FN3O/c1-31-25-12-10-20(22-11-9-18(16-28)14-23(22)27)15-21(25)17-30-24-8-5-13-29-26(24)19-6-3-2-4-7-19/h2-4,6-7,9-12,14-15,24,26,29-30H,5,8,13,17H2,1H3/t24-,26-/m0/s1
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InChIKey |
BJOOHYLOKXAENV-AHWVRZQESA-N
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Substance-P receptor (TACR1) | Target Info | Antagonist | [2] |
KEGG Pathway | Calcium signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Measles | ||||
Panther Pathway | CCKR signaling map ST | |||
Reactome | G alpha (q) signalling events | |||
WikiPathways | SIDS Susceptibility Pathways | |||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
Spinal Cord Injury | ||||
Peptide GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5746). | |||
REF 2 | Pharmacological characterization of T-2328, 2-fluoro-4'-methoxy-3'-[[[(2S,3S)-2-phenyl-3-piperidinyl]amino]methyl]-[1,1'-biphenyl]-4-carbonitrile d... J Pharmacol Sci. 2008 Jan;106(1):121-7. |
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