Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0L7BV
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| Former ID |
DIB004294
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| Drug Name |
Gevotroline
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| Synonyms |
Carvotroline; Carvotroline hydrochloride; Gevotroline hydrochloride; WY-47384; WY-47791; Wy-46320
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| Drug Type |
Small molecular drug
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| Indication | Psychotic disorder [ICD-11: 6A20-6A25] | Discontinued in Phase 1 | [1] | |
| Company |
Wyeth; Wyeth-Ayerst Pharmaceuticals Inc
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| Structure |
 |
Download2D MOL |
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| Formula |
C19H20FN3
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| Canonical SMILES |
C1CN(CC2=C1NC3=C2C=C(C=C3)F)CCCC4=CN=CC=C4
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| InChI |
1S/C19H20FN3/c20-15-5-6-18-16(11-15)17-13-23(10-7-19(17)22-18)9-2-4-14-3-1-8-21-12-14/h1,3,5-6,8,11-12,22H,2,4,7,9-10,13H2
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| InChIKey |
RZXHTPCHKSYGIB-UHFFFAOYSA-N
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| CAS Number |
CAS 107266-06-8
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:142391
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Opioid receptor sigma 1 (OPRS1) | Target Info | Modulator | [2], [3] |
| WikiPathways | miR-targeted genes in squamous cell - TarBase | |||
| miR-targeted genes in lymphocytes - TarBase | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001398) | |||
| REF 2 | Sigma receptor ligands alter concentrations of corticosterone in plasma in the rat. Neuropharmacology. 1991 Jan;30(1):79-87. | |||
| REF 3 | Neuroendocrinological and neurochemical effects of sigma ligands. Neuropharmacology. 1992 Feb;31(2):157-62. | |||
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