Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0L7FM
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| Former ID |
DAP001292
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| Drug Name |
Probenecid
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| Synonyms |
Apurina; Bencid; Benecid; Benemid; Benemide; Benuryl; Panuric; Parabenem; Probalan; Probampacin; Probecid; Proben; Probenecida; Probenecide; Probenecidum; Probenemid; Probenicid; Probenid; Probexin; Prolongine; Robenecid; Sulprin; Tubophan; Uricosid; Urocid; Biokanol Brand of Probenecid; ICN Brand of Probenecid; IDIS Brand of Probenecid; Major Brand of Probenecid; Martec Brand of Probenecid; Merck Brand of Probenecid; Ophthalmic Brand of Probenecid; Parmed Brand of Probenecid; Probenecid Major Brand; Probenecid Martec Brand; Probenecid Parmed Brand; Probenecid Weimer; Probenecid Zenith Brand; Probenecid acid; Synergid R; Valdecasas Brand of Probenecid; Zenith Brand of Probenecid; Benemid (TN); Benuryl (TN); Col-BENEMID; ColBenemid (co mponent of); ColBenemid (component of); P-[Dipropylsulfamoyl]benzoic acid; Polycillin-BRB; Pro-Cid; Probenecida [INN-Spanish]; Probenecide [INN-French]; Probenecidum [INN-Latin]; P-(Dipropylsulfamoyl)benzoic acid; P-(Dipropylsulfamyl)benzoic acid; Polycillin-PRB (component of); Probenecid [INN:BAN:JAN]; Probenecid (JP15/USP/INN); 4-((Dipropylamino)sulfonyl)benzoic acid;4-(Di-n-propylsulfamoyl)benzoesaeure; 4-(Dipropylsulfamoyl)benzoic acid; 4-(N,N-Dipropylsulfamoyl)benzoesaeure; 4-[(dipropylamino)sulfonyl]benzoic acid
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| Drug Type |
Small molecular drug
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| Indication | Gout [ICD-11: FA25; ICD-10: M10] | Approved | [1], [2], [3] | |
| Hyperuricaemia [ICD-11: 5C55.Y] | Approved | [1], [2], [3] | ||
| Therapeutic Class |
Uricosuric Agents
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| Structure |
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Download2D MOL |
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| Formula |
C13H19NO4S
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| Canonical SMILES |
CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(=O)O
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| InChI |
1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16)
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| InChIKey |
DBABZHXKTCFAPX-UHFFFAOYSA-N
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| CAS Number |
CAS 57-66-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9576, 81789, 855953, 3162120, 5227618, 7847541, 7980385, 8149496, 8153022, 10321755, 10528000, 11112135, 11335231, 11360470, 11363728, 11366290, 11368852, 11371827, 11374110, 11377014, 11461442, 11466570, 11467690, 11485063, 11486240, 11489110, 11490370, 11492301, 11494648, 14873183, 17389752, 24898976, 26611889, 26680013, 26747055, 26747056, 26751571, 29223989, 46506554, 47588826, 47662104, 47885248, 47959564, 47959565, 48034940, 48110289, 48334309, 48414371, 48416470, 48423998
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| ChEBI ID |
CHEBI:8426
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| ADReCS Drug ID | BADD_D01841 | |||
| SuperDrug ATC ID |
M04AB01
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| SuperDrug CAS ID |
cas=000057669
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
| Studied Microbe: Gut microbiota unspecific | [4] | |||
| Experimental Method | High-throughput screening | |||
| Description | Probenecid can be metabolized by gut microbiota. | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Solute carrier family 22 member 8 (SLC22A8) | Target Info | Blocker | [5], [6] |
| Pathwhiz Pathway | Kidney Function | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4357). | |||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 3 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 007898. | |||
| REF 4 | Personalized Mapping of Drug Metabolism by the Human Gut Microbiome. Cell. 2020 Jun 25;181(7):1661-1679.e22. | |||
| REF 5 | Transport of organic anions across the basolateral membrane of proximal tubule cells. Rev Physiol Biochem Pharmacol. 2003;146:95-158. | |||
| REF 6 | Interactions of organic anions with the organic cation transporter in renal BBMV. Am J Physiol. 1988 Jan;254(1 Pt 2):F56-61. | |||
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