Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0L8MR
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| Former ID |
DNC013047
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| Drug Name |
MESCALINE
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| Synonyms |
mescaline; Mescalin; Tmpea; Mezcaline; 3,4,5-Trimethoxyphenethylamine; 54-04-6; 2-(3,4,5-Trimethoxyphenyl)ethanamine; 3,4,5-Trimethoxyphenylethylamine; Mezcalin; 3,4,5-Trimethoxybenzeneethanamine; mezcalina; mescalina; Meskalin; Benzeneethanamine, 3,4,5-trimethoxy-; Mescalin [German]; Mescline; Mezcline; Phenethylamine, 3,4,5-trimethoxy-; UNII-RHO99102VC; NSC 30419; Ethane, 1-amino-2-(3,4,5-trimethoxyphenyl)-; EINECS 200-190-7; BRN 1374088; 2-(3,4,5-trimethoxy-phenyl)-ethylamine; CHEMBL26687; RHO99102VC
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C11H17NO3
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| Canonical SMILES |
COC1=CC(=CC(=C1OC)OC)CCN
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| InChI |
1S/C11H17NO3/c1-13-9-6-8(4-5-12)7-10(14-2)11(9)15-3/h6-7H,4-5,12H2,1-3H3
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| InChIKey |
RHCSKNNOAZULRK-UHFFFAOYSA-N
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| CAS Number |
CAS 54-04-6
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:28346
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 2A receptor (HTR2A) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Serotonergic synapse | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | 5HT2 type receptor mediated signaling pathway | |||
| Reactome | Serotonin receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Serotonin Receptor 2 and STAT3 Signaling | |||
| Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | ||||
| SIDS Susceptibility Pathways | ||||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands. Bioorg Med Chem. 2008 Apr 15;16(8):4661-9. | |||
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