Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0L8QQ
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| Former ID |
DNC003711
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| Drug Name |
VELNACRINE
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| Synonyms |
Velnacrine; 124027-47-0; 1-hydroxytacrine; 9-amino-1,2,3,4-tetrahydroacridin-1-ol; Velnacrine [INN:BAN]; Velnacrinum [INN-Latin]; Velnacrina [INN-Spanish]; 1-Acridinol,9-amino-1,2,3,4-tetrahydro-; 104675-29-8; 1-Acridinol, 9-amino-1,2,3,4-tetrahydro-; UNII-JFN3Z63E2C; UNII-OQL6V4U301; JFN3Z63E2C; CHEMBL51934; OQL6V4U301; HLVVITIHAZBPKB-UHFFFAOYSA-N; AK160411; Velnacrinum; Velnacrina; 112964-98-4; Velnacrine, (+)-; 9-ATHCO; 1-hydroxy-tacrine; 1-Hydroxy Tacrine; 121445-17-8; ACMC-20ddjc; Velnacrine, (-)-; Spectrum_000073; AC1Q7AWG
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| Drug Type |
Small molecular drug
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| Indication | Cognitive impairment [ICD-11: 6D71; ICD-10: F06.7] | Discontinued in Phase 3 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C13H14N2O
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| Canonical SMILES |
C1CC(C2=C(C3=CC=CC=C3N=C2C1)N)O
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| InChI |
1S/C13H14N2O/c14-13-8-4-1-2-5-9(8)15-10-6-3-7-11(16)12(10)13/h1-2,4-5,11,16H,3,6-7H2,(H2,14,15)
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| InChIKey |
HLVVITIHAZBPKB-UHFFFAOYSA-N
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| CAS Number |
CAS 124027-47-0
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:91990
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Acetylcholinesterase (AChE) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Glycerophospholipid metabolism | |||
| Cholinergic synapse | ||||
| Panther Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |||
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway | ||||
| Nicotinic acetylcholine receptor signaling pathway | ||||
| Pathwhiz Pathway | Phospholipid Biosynthesis | |||
| Pathway Interaction Database | ATF-2 transcription factor network | |||
| WikiPathways | Monoamine Transport | |||
| Biogenic Amine Synthesis | ||||
| Acetylcholine Synthesis | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Velnacrine for Alzheimer's disease. Cochrane Database Syst Rev. 2004;(2):CD004748. | |||
| REF 2 | Synthesis and biological activity of putative mono-hydroxylated metabolites of velnacrine, Bioorg. Med. Chem. Lett. 2(8):865-870 (1992). | |||
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